Biochem/physiol Actions

Reversible: no

Product competes with ATP.

Target K_i: 77 nM against Casein Kinase II

Cell permeable: yes

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pagano, M.A., et al. 2006. Chembiochem8, 129

Packaging

Packaged under inert gas

5 mg in Plastic Bag(s)

Warning

Toxicity: Irritant (B)